Pharmaceutical Manufacturing magazine has published an article titled "Low-Risk Lyophilization" which discusses the design and construction of a new cytotoxic / genotoxic production facility. This facility uses Hull lyophilizers with Multi-Flex and SmartCool heat transfer loop control and Variable Frequency Drive (VFD) screw compressors with LN2 backup for refrigeration. The freeze dryers use autolocking chamber doors with sub-doors, autopositioning shelves, and fluid loop condensing.
View the March, 2009, Pharmaceutical Manufacturing magazine article here.
|
Hull Lyophilizer Technology Examples
Hull has developed a great understanding of the Pharmaceutical Industry's needs in over 45 years of engineering, fabricating, and assembling standard and custom lyophilizer systems. We have worked closely with our customers to manufacture cost-effective, reliable solutions to meet their individual lyophilization requirements. We look forward to working with you.
Here is a brief survey of a few of our recent projects:
|
220FXS450-SS25C
Parenteral Production
- Liquid Nitrogen (LN2)
- Auto Locking Door
|
360FXS700-SS30C
Veterinary Production
- Cascade Refrigeration
- 2-Stage Recipricating Compressors
- Auto Locking Door
- Vertically Oriented Tube-Coil Condenser
|
300FXS-450-SS20C
Parenteral Production
- 2-Stage Reciprocating Compressors
- Auto Locking Door
- Smart Cool DX Condensor
|
|
36FXS50C-SS30C
Research & Development and Pilot
- Auto Temperature Controlled
Chamber & Door via Fluid Jacket
- Auto Locking Door
- Hypro Condenser
- CIP Recirculation System
- Sampling Thief
- Clean In Place
- Steam In Place
|
450FXS800-SS25C
Parenteral Production
- Screw Compressors
- Auto Locking Door
- Sub-door for Autoloading
- Dual-Loop Brine Heat Transfer
- Hypro Condenser
- Clean In Place
- Steam In Place
|
120FS175-SS25C
Parenteral Production
- 2-Stage Reciprocating Compressors
- Tee-handle Door
- Water Cooled Chamber and Door Jackets
- Internal Condenser Plates
- 2-Story Plant Installation
- Clean In Place
- Steam In Place
|
|
300FXS450-SS25C
Parenteral Production
- Auto Loading
Hull Loader feeds Two Lyophilizers
- Screw compressors with LN2 Backup
- Central Brine Heat Transfer
- Hypro Condenser
- Clean In Place
- Steam In Place
|
420FXS800-SS30C
Parenteral Production
- Screw Compressors
- Auto Locking Door
- Water Cooled Chamber & Door Jackets
- Vertically Mounted Condensers
- Tube Coil Condensing
- Recirculating CIP System
- Clean In Place
- Steam In Place
|
360FXS450-SS25C
Parenteral Production -Retrofit
- 2-Stage Recipricating Compressors
- Converted from 280 Sq.Ft to 360 Sq.Ft
(Retrofitted 4 shelves)
- New Hypro Condenser
- New Control Package
|
|
Standard Freeze Dryer Options
Refrigeration
- Reciprocating Compressors
- Screw Compressors
- LN2 Refrigeration
- Cascade Refrigeration
- Smart Cool®
Heat Transfer
- Direct Expansion Condensing
- Flooded Loop Condensing
- Internal Condensing
- External Condensing
- Hypro® Condensing
|
Vacuum
- Rotary Vane Vacuum Pumps
- Rotary Piston Vacuum Pumps
- Mecanical Booster Vacuum Pumps
- Liquid Ring Vacuum Pumps
Sterilization
- Clean-in-Place
- Steam-in-Place
- Vapor Hydrogen Peroxide
|
Loading
- Tee-handle doors
- Auto-locking doors
- Sub-doors
- Semi-Manual Loaders & Unloaders
- Autoloading & Unloading
Retrofits
- Controls Upgrades
- Refrigeration Upgrades
- Product Shelves
- Process Vessels
|
Compliance
- GAMP4
- 21 CFR 210
- 21 CFR 211
- ASME Sect.VIII Div.1 Pressure Vessels
- Seismic Certification
Documentation
- Borescope Maps
- Materials
- System Integration Testing
- Factory Acceptance Testing
- Installation Qualification
- Operational Qualification
|
|
Hull excels at custom lyophilization systems:
Click Here to Request Your Custom Freeze Dryer Quote
Complete installation, startup, and training services are available to help you bring your lyophilization suite online quickly. We also provide preventative maintenance contracts and service and parts support to help you maintain your lyophilizer at optimum efficiency.
|
|
